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KMID : 0043320120350071287
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Archives of Pharmacal Research
2012 Volume.35 No. 7 p.1287 ~ p.1292
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Inhibitory effect of dibutyryl chitin ester on nitric oxide and prostaglandin E2 production in LPS-stimulated RAW 264.7 cells
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Jeon In-Hwa
Mok Ji-Ye
Park Kwang-Hyun
Song Mi-Seon
Lee Duck-Hee
Lee Min-Hee
Lee Woo-Yiel
Chai Kyu-Yun
Jang Seon-Il
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Abstract
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Inflammation is a highly complex process that protects against foreign challenge or tissue injury. The ester derivative dibutyryl chitin (DBC) reportedly accelerates wound healing and exerts an anti-inflammatory effect. However, little is known regarding the inhibitory effect of DBC in anti-inflammation. In this study, we investigated the effect of DBC on the inducible nitric oxide synthetase (iNOS) and cyclooxygenage-2 (COX-2) pathways and pro-inflammatory cytokine production in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. Our results demonstrate that DBC (MW 3,772) significantly inhibits overproduction of NO and PGE2 as well as pro-inflammatory cytokines, such as tumor necrosis factor-α and interleukin-1β, in LPS-stimulated RAW 264.7 macrophages. Inhibition of NO and PGE2 overproduction in LPSstimulated RAW 264.7 macrophages by DBC was mediated through the down-regulation of iNOS and COX-2 expression. These results demonstrate that DBC efficiently inhibits inflammation and has potential as an effective anti-inflammatory and wound healing agent.
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KEYWORD
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Dibutyl chitin ester, Nitric oxide, Prostaglandin E2, Pro-inflammatory cytokines, Anti-inflammatory effect
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